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IgE binding to the FcεRI results in FcεRI aggregation, then downstream phosphorylation of immunoreceptor tyrosine-based activated motifs on the receptor subunits, activation of spleen tyrosine kinase (SYK), phosphoinositide 3-kinase (PI3K), and Bruton’s tyrosine kinase (BTK) with ultimate downstream release of inflammatory mediators [84]